Erratum: Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions
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چکیده
منابع مشابه
TRs have common and isoform-specific functions in regulation of the cardiac myosin heavy chain genes.
TRalpha1 and TRbeta mediate the regulatory effects of T3 and have profound effects on the cardiovascular system. We have analyzed the expression of the cardiac myosin heavy chain (MyHC) genes alpha and beta in mouse strains deficient for one or several TR genes to identify specific regulatory functions of TRalpha1 and TRbeta. The results show that TRalpha1 deficiency, which slows the heart rate...
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Platelets are central to haemostasis and thrombosis. Many key steps in platelet activation and aggregation are regulated by members of the PKC (protein kinase C) family. Multiple isoforms of PKC are expressed in platelets, and evidence is emerging that different isoforms play distinct roles in the platelet activation process. This may, in part, be regulated by isoform-specific interactions betw...
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Pre-mRNA splicing is required for the accurate expression of virtually all human protein coding genes. However, splicing also plays important roles in coordinating subsequent steps of pre-mRNA processing such as polyadenylation and mRNA export. Here, we test the hypothesis that nuclear pre-mRNA processing influences the polyribosome association of alternative mRNA isoforms. By comparing isoform...
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We repeatedly toss a biased coin where the probability is p of observing “heads”. The probability of a certain event can be regarded as a function of p. L. Lovász asked for a characterization of the functions occurring as the probability of some “reasonable” event. We state this problem in precise terms by introducing the concept of an “observable” event. Our main theorem states that a function...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2018
ISSN: 0022-2275
DOI: 10.1194/jlr.m079996err